Enhanced Fluoride Uptake of LISTERINE® Anticavity Mouthwash

An advanced technology enhances fluoride uptake.


Dental professionals know that fluoride is one of the keys to good oral health. Sometimes called “nature’s cavity fighter,” fluoride is a naturally occurring mineral that helps prevent cavities in children and adults by making enamel more resistant to acid-producing bacteria that cause dental caries. Fluoride not only helps prevent caries, but can also repair teeth in the very early, microscopic stages.1,2

The use of toothpaste with fluoride has been responsible for a significant drop in cavities since 1960. More recently, mouthrinses with fluoride have also been shown to make teeth more resistant to decay.2 There are, of course, various brands and types to choose from, and on the surface it might appear that all fluoride-containing mouthrinses are the same. But appearances can be deceiving.

LISTERINE® products strive for unique innovations designed to strengthen the value of the recommendations of oral healthcare professionals. With this in mind, LISTERINE® created anticavity mouthwashes powered by RAPID FUSION TECHNOLOGY®.

RAPID FUSION TECHNOLOGY® rapidly binds calcium ions with fluoride to create fluoride reservoirs. These reservoirs attach to enamel and are then released over time for a greater fluoride uptake3 and greater enamel content of fluoride to the tooth surface. 

When compared to ACT® fluoride rinses, LISTERINE® TOTAL CARE has up to a 7x greater fluoride uptake.3*

Chart showing Enamel Fluoride Concentration demonstrates that LISTERINE® TOTAL CARE Anticavity Mouthwash has up to 7X greater fluoride uptake—9055 PPM 2X/day vs 1118 PPM for ACT® Total Care Anticavity fluoride rinse 2X/day, and 1540 PPM 1X/day.

Additionally, LISTERINE® TOTAL CARE demonstrates:

  • 68% greater remineralization of enamel compared to ACT® Total Care Fluoride Rinse3*
  • 50% more tooth strengthening than with fluoride rinse toothpaste alone3‡

In order to demonstrate the proven science behind RAPID FUSION TECHNOLOGY®, we’ve created this short video for your viewing pleasure.


Your recommendation is important to your patients and it’s important to us. By suggesting that patients use LISTERINE® Anticavity mouthrinses twice daily to enhance their ability to fight cavities, you can feel confident that you’ve recommended a fluoride rinse that may work better.

We hope you found this article of value.

Learn more about the breakthrough technology behind LISTERINE® Fluoride products.

Discover which LISTERINE® Anticavity products you should consider recommending to your patients.

*Compared to ACT® Total Care Anticavity Fluoride Rinse, ACT® Total Care Anticavity Fluoride Rinse-Alcohol Free, ACT ® Total Care Anticavity Fluoride Mouthwash, ACT® Restoring™ Anticavity Mouthwash, and ACT ® Anticavity Kids Fluoride Rinse in a laboratory study.
In a laboratory study.
Compared to Crest® Fluoride toothpaste and rinsing with water in a laboratory study.
The third-party trademarks used herein are trademarks of their respective owners.

1. Fluoride treatments in the dental office. JADA. 2007;138. http://www.ada.org/~/media/ADA/Member%20Center/FIles/patient_72.ashx. Accessed April 11, 2016.
2. Fluoride. Mouth Healthy/American Dental Association Web site. https://www.mouthhealthy.org/en/az-topics/f/fluoride. Accessed April 11, 2016.
3. Data on file, Johnson & Johnson Consumer Inc.