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Comparative Effects of 2 Chemotherapeutic Mouthrinses on the Development of Supragingival Dental Plaque and Gingivitis<sup>1,2</sup>

Comparative Effects of 2 Chemotherapeutic Mouthrinses on the Development of Supragingival Dental Plaque and Gingivitis1,2

- Overholser CD, Meiller TF, DePaola LG, Minah GE, Niehaus C. Comparative effects of 2 chemotherapeutic mouthrinses on the development of supragingival dental plaque and gingivitis. J Clin Periodontol. 1990;17:575-579.

 

PeridexTM vs LISTERINE® for Gingivitis and Dental Plaque

Objective

Determine the efficacy of 2 mouthrinses—LISTERINE® Antiseptic and Peridex™—used as supplements to regular oral hygiene measures in reducing supragingival dental plaque and gingivitis (N=124). 

 

Methodology

Double-blind, controlled, parallel design clinical study of healthy male and female subjects (aged ≥21 years) with preexisting plaque and gingivitis but without evidence of periodontitis. 

Methodology

 

Results

At 6 months, gingivitis development was inhibited by 35.9% in the LISTERINE® Antiseptic group and by 30.5% in the Peridex™ group, when compared to the hydroalcohol control (P<0.001).

At 6 months, gingivitis development—in posterior regions—was inhibited by 33.2% and 34.4% in the LISTERINE® Antiseptic group and by 26.6% and 33.8% in the Peridex™ group, when compared to the hydroalcohol control (P<0.001).2

Chart

Conclusion

LISTERINE® Antiseptic produces gingivitis reductions comparable to Peridex™ at 6 months (including gingivitis in posterior regions).

Comparative effects of 2 chemotherapeutic mouthrinses on the development of supragingival dental plaque and gingivitis1, 2 - footnotes/references

*LISTERINE® Antiseptic is not indicated for use in the treatment of xerostomia.
During the study, subjects followed their usual oral hygiene and dietary habits.

References: 1. Overholser CD, Meiller TF, DePaola LG, Minah GE, Niehaus C. Comparative effects of 2 chemotherapeutic mouthrinses on the development of supragingival dental plaque and gingivitis. J Clin Periodontol. 1990;17:575-579. 2. Data on file, Johnson & Johnson Consumer Inc.