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Walker C et al (1989)
EVALUATION OF MICROBIAL SHIFTS IN SUPRAGINGIVAL PLAQUE FOLLOWING LONG—TERM USE OF AN ORAL ANTISEPTIC MOUTHRINSE1
Objective
To determine the effect of long-term use of LISTERINE® Antiseptic
mouthrinse on microbial composition of supragingival dental plaque.
Methods
A subset of 40 subjects participating in a 6-month trial completed this
assessment. Subjects rinsed unsupervised with LISTERINE® Antiseptic
or a 5% hydroalcohol control twice daily in addition to normal oral hygiene.
Supragingival plaque was evaluated at baseline and at 3 and 6 months for
bacterial composition, based on dark-field microscopy, culture on selective and
non-selective media and enumeration by colony morphology.
Results
No significant differences in bacterial composition of supragingival plaque
were found. Additionally, no opportunistic pathogens—such as yeast, enteric
bacteria, or staphylococci—emerged.
The authors concluded that long-term use of LISTERINE® Antiseptic results in a decrease in total supragingival plaque and does not produce a shift in the microbial composition of this plaque that would be detrimental to oral health.
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REFERENCES
- Walker C, Clark W, Wheeler T, Lamm R. Evaluation of microbial shifts in supragingival plaque following long-term use of an oral antiseptic mouthrinse. J Dent Res. 1989;68:412. Abstr 1845.