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Overholser CD et al (1990)
COMPARATIVE EFFECTS OF 2 CHEMOTHERAPEUTIC MOUTHRINSES ON THE DEVELOPMENT OF SUPRAGINGIVAL DENTAL PLAQUE AND GINGIVITIS1
Objective
To determine the efficacy and safety of LISTERINE® Antiseptic and
Peridex in helping to control supragingival plaque and gingivitis when used as
an adjunct to normal oral hygiene routine and regular professional care.
Methods
This was a 6&endash;month, randomized, double&endash;blind, supervised, controlled clinical
study in which 124 adult subjects received a professional dental prophylaxis
and then rinsed for 30 seconds twice a day for 6 months with 20 mL of either
LISTERINE® Antiseptic, Peridex, or a 5% hydroalcohol control rinse
in addition to their normal oral routine. Subjects were provided with a soft
nylon toothbrush and fluoride toothpaste and were asked not to use any other
mouthrinses during the study. At baseline and at 3 and 6 months, subjects were
evaluated for gingivitis, supragingival plaque, extrinsic tooth stain, and
supragingival calculus formation.
Results
At 6 months, LISTERINE® Antiseptic produced a 36.1% inhibition of
supragingival plaque development and a 35.9% inhibition of gingivitis
development compared with the control group. Peridex provided a 50.3% reduction
for plaque and 30.5% reduction for gingivitis compared to the control. There
were no significant increases in either extrinsic tooth stain or supragingival
calculus compared to baseline scores in either the LISTERINE® Antiseptic
or the control group.
LISTERINE® Results
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REFERENCES
- Overholser CD, Meiller TF, DePaola LG, Minah GE, Niehaus C. Comparative effects of 2 chemotherapeutic mouthrinses on the development of supragingival dental plaque and gingivitis. J Clin Periodontol. 1990;17:575-579.