An Unmatched Clinical History
The efficacy of Listerine^® Antiseptic in improving overall oral health has been rigorously studied over the last 3 decades in more than 30 published clinical studies. There have been several focuses of study:

Plaque and Gingivitis
Adjunctive use of Listerine^® Antiseptic has been proven in multiple long-term clinical studies to significantly inhibit supragingival plaque by up to 56% and gingivitis by up to 36%—even in hard-to-reach areas.

• Overholser et al (1990)
• DePaola et al (1989)
• Charles et al (2001)
• Gordon et al (1985)
• Charles et al (2004)
• Sharma et al (2004)
• Lamster et al (1983)
• Ciancio SG et al (1995)

Broad-Spectrum Antimicrobial Activity
The diversity of the flora associated with plaque and gingivitis makes controlling these conditions a complex challenge. Listerine^® Antiseptic has been proven to rapidly kill—within 30 seconds of exposure—a broad spectrum of bacteria, including 20 species associated with overall oral health.¹

• Fine DH et al (2000)
• Charles CH et al (2000)

Germ Kill
Listerine^® Antiseptic is clinically proven to kill germs for 12-hour plaque and gingivitis protection. Twelve-hour germ kill means that patients who rinse twice daily will benefit from around-the-clock protection.

• Fine DH et al (2005)
• Pan P et al (2000)

Dispelling Myths About Listerine^® – Long-Term Safety
Listerine^® Antiseptic can be safely and confidently used for extended periods because it does not disturb the balance of oral flora and is not associated with oral cancer risk or increased oral dryness.

          Effect on Oral Flora

• Walker C et al (1989)
• Minah GE et al (1989)

          Alcohol-Containing Mouthrinses

• Cole P et al (2003)
• Elmore JG, Horwitz RI (1995 )
• Federal Register (2003)

          Dry Mouth

• Fischman SL et al (2004)

REFERENCES

1. Ross NM, Charles CH, Dills SS. Long-term effects of Listerine Antiseptic on dental plaque and gingivitis.
   J Clin Dent. 1989;1:92-95.