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Gordon JM et al (1985)
EFFICACY OF LISTERINE® ANTISEPTIC IN INHIBITING THE DEVELOPMENT OF PLAQUE AND GINGIVITIS1
Objective
To determine the efficacy of Listerine® Antiseptic in inhibiting the
development of plaque and gingivitis.
Methods
This was a 9-month, randomized, double-blind, controlled clinical trial in
which 85 adult subjects completed all phases of the study. Subjects received
three complete professional dental prophylaxes at weekly intervals and an
additional rubber-cup polishing at the outset of the study to maximize initial
gingival health and reduce plaque to zero. Subjects rinsed with 20 mL of
Listerine® Antiseptic, a vehicle control, or a water control for 30
seconds twice daily, in addition to their usual oral hygiene. During the first
6 months, rinsing was supervised on weekdays; rinsing was unsupervised during
the final 3 months. Subjects were periodically given a nontherapeutic,
low-abrasive dentifrice and soft nylon toothbrushes, and were asked not to use
any mouthrinses that were not provided for the study.
Results
Listerine® Antiseptic group had significantly lower plaque scores
than in the vehicle control group by 18.6% and 13.8%, respectively, at 6 and 9
months. Although there was virtually no change in gingivitis in the control
group over the 9-month period following the multiple prophylaxes, gingivitis in
the Listerine® Antiseptic group was reduced significantly by
22.1% compared with the vehicle control group at the conclusion of the 9-month
study.
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REFERENCES
- Gordon JM, Lamster IB, Seiger MC. Efficacy of Listerine antiseptic in inhibiting the development of plaque and gingivitis. J Clin Periodontol. 1985;12:697-704.