Charles CH et al (2001)

COMPARATIVE EFFICACY OF AN ANTISEPTIC MOUTHRINSE AND AN ANTIPLAQUE/ANTIGINGIVITIS DENTIFRICE: A SIX-MONTH CLINICAL TRIAL¹

Objective
To determine the comparative efficacy of LISTERINE^® Antiseptic and COLGATE TOTAL^®, an antiplaque/antigingivitis dentifrice.

Methods
In this 6-month, randomized, unsupervised, controlled clinical trial, 316 subjects with mild–to–moderate gingival inflammation and plaque received a dental prophylaxis and were assigned to one of the following regimens: control (fluoride) toothpaste/LISTERINE^® Antiseptic: Colgate Total/control (inactive) rinse; or a control regimen (fluoride toothpaste/inactive rinse). Subjects were instructed not to use any other mouthrinses or dentifrices during the study. At baseline, 3 months, and 6 months, the examiner performed an intraoral exam, scoring for modified gingival index, bleeding index, and plaque index.

Results
Both active regimens demonstrated significantly greater reductions vs the control regimen in all three measured parameters (p< 0.001). The LISTERINE^® Antiseptic regimen was no different than the Colgate regimen in reducing the gingivitis index but was significantly more effective in reducing the bleeding index (p=0.033) and the plaque index (p< 0.001). However, the magnitude of the difference in the bleeding index was small.

While the active treatment groups produced similar reductions in gingivitis, LISTERINE^® Antiseptic provided greater benefit in inhibiting plaque formation when used with a fluoride dentifrice.

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REFERENCES

1. Charles CH, Sharma NC, Galustians HJ, Qaqish J, McGuire JA, Vincent JW. Comparative efficacy of an antiseptic mouthrinse and an antiplaque/antigingivitis dentifrice: a six-month clinical trial. J Am Dent Assoc. 2001;132:670-675.