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Proven to Penetrate Plaque Biofilm
LISTERINE® Antiseptic penetrates plaque biofilm to rapidly kill bacteria associated with plaque and gingivitis. Use of plaque biofilm models is representative of antimicrobial activity in the oral cavity.
  • Bacteria in biofilm are more resistant to antimicrobial agents1,2
  • In germ-kill studies, LISTERINE® has been proven to kill a broad spectrum of microorganisms, including 20 distinct species for overall oral health3
  • Kills 7 essential species of microorganisms that lead to plaque and gingivitis3
  • Proven to work on the teeth, between the teeth, and just below the gumline, killing bacteria in hard-to-reach areas4-7
  • The germ-killing power of LISTERINE® Antiseptic was unaffected by the presence or absence of serum3,5,8

REFERENCES

  1. Ouhayoun J-P. Penetrating the plaque biofilm: impact of essential oil mouthwash. J Clin Periodontol. 2003;30(suppl5):10-12.
  2. Pan P, Barnett ML, Coelho J, Brogdon C, Finnegan MB. Determination of the in situ bactericidal activity of an essential oil mouthrinse using a vital stain method. J Clin Periodontol. 2000;27:256-261.
  3. Ross NM, Charles CH, Dills SS. Long-term effects of LISTERINE® Antiseptic on dental plaque and gingivitis. J Clin Dent. 1989;1:92-95.
  4. Charles CH, Pan PC, Sturdivant L, Vincent JW. In vivo antimicrobial activity of an essential oil-containing mouthrinse on interproximal plaque bacteria.J Clin Dent. 2000;11:94-97.
  5. Fine DH, Furgang D, Barnett ML, et al. Effect of an essential oil-containing antiseptic mouthrinse on plaque and salivary Streptococcus mutans levels. J Clin Periodontol. 2000;27:157-161.
  6. Furgang D, Markowitz K, Goldsmith D, Charles C, Lynch M, Fine D. Antimicrobial mouthrinse reduces subgingival plaque organisims after two weeks use. The IADR/AADR/CADR 83 Rd General Session (March 9-12, 2005), Baltimore, MD. Abstract 2596.
  7. Pianotti R, Pitts G. Effects of an antiseptic mouthwash on odorigenic microbes in the human gingival crevice. J Dent Res. 1978;57(2):175-179.
  8. Fine DH, Furgang D, Sinatra K, Charles C, McGuire A, Kumar LD. In vivo antimicrobial effectiveness of an essential oil-containing mouth rinse 12 h after a single use and 14 days use. J Clin Periodontol. 2005;32:335-340.